Description
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid mitochondrial-derived peptide known for its potent regulation of metabolic homeostasis. It functions primarily by activating the AMP-activated protein kinase (AMPK) pathway, a critical cellular energy sensor that modulates glucose uptake and fatty acid oxidation. Research indicates that MOTS-c acts as an exercise-mimetic signal, promoting insulin sensitivity and preventing diet-induced obesity in experimental models.

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