HGH-Fragment 176-191

Name: HGH-Fragment 176-191 - Oxford Peptide Labs
Price: 37.90 GBP
Availability: InStock

£37.90

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High-purity HGH-Fragment 176-191 lyophilized powder for research into targeted lipolysis and metabolic regulation without glycemic impact.

Description

HGH-Fragment 176-191 is a synthetic peptide analogue of the C-terminus of human growth hormone (amino acids 176-191). This fragment has been isolated for its specific ability to stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (the formation of fat) without exerting the anabolic or glycemic side effects associated with the intact growth hormone molecule. Research suggests it mimics the natural fat-metabolizing pathways of HGH, making it a primary subject of interest in obesity and metabolic studies.

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Category Peptides Tags mg, Peptides, Vial Brand: Oxford Peptide Labs

Please note if you have a different Batch ID please contact us for the latest COA.

Chemical Specifications:

Chemical Name: HGH Fragment 176-191
Synonyms: Tyr-hGH176-191, AOD-9604 (modified variant), Growth Hormone Peptide Fragment 176-191
CAS Number: 66004-57-7
Molecular Formula: C${78} $H$ {125} $N$ {23} $O$ {23} $S$ _{2}$
Molecular Weight: 1817.12 g/mol
Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Structure: Linear peptide chain (C-terminal region of HGH)

Description & Mechanism

Applications in Research

Lipid Metabolism Research: Investigated for its ability to increase lipolytic activity in adipose tissue.
Obesity Studies: Used to understand mechanisms of fat reduction without affecting blood glucose levels or cell proliferation.
Cartilage Regeneration: Some studies explore the potential of the fragment (specifically the AOD9604 variant) in cartilage repair and collagen production.
Glycemic Control: Unlike full-chain HGH, Fragment 176-191 is studied for its lack of impact on insulin sensitivity.

Handling, Reconstitution & Stability

Formulation: Lyophilized powder.
Storage: -20°C for powder, -80°C for reconstituted solution. Avoid repeated freeze-thaw cycles.
Reconstitution: Bacteriostatic water or sterile saline.

Specifications Summary

Purity: ≥99% (HPLC)
Grade: Research Grade
Appearance: White lyophilized powder
Solubility: Soluble in water, saline, or dilute acetic acid.

Precautions & Notes

For Research Use Only. Not for human consumption. While HGH Fragment 176-191 does not typically interact with the HGH receptor to induce IGF-1 release, proper laboratory safety protocols must be followed. It is not intended for diagnostic or therapeutic use in humans or animals. Research indicates it lacks the growth-promoting effects of the full HGH molecule.

References

Ng, F. M., et al. (2000). Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Journal of Molecular Endocrinology, 8(5), 601-610.
Heffernan, M., et al. (2001). The effects of human growth hormone and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and β3-AR knock-out mice. Endocrinology, 142(12), 5182-5189.
Cox, H. D., et al. (2015). Detection of human growth hormone variant AOD9604 in urine. Drug Testing and Analysis, 7(10), 947-951.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.