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AOD9604 is a modified synthetic fragment corresponding to residues 176–191 of the C-terminal region of human growth hormone (hGH). It is primarily researched for its potential to stimulate lipolysis (fat breakdown) and inhibit lipogenesis (fat accumulation) without the glycemic or growth-promoting effects associated with full-length hGH. This peptide is widely utilized in studies focusing on metabolic regulation and obesity management.
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Chemical Name: AOD9604
Synonyms: HGH Fragment 176-191 analogue, AOD 9604, Anti-Obesity Drug 9604
CAS Number: 221231-10-3
Molecular Formula: C${78}$H${123}$N${23}$O${23}$S
Molecular Weight: 1815.1 g/mol
Sequence: Tyr–Leu–Arg–Ile–Ala–Asp–Leu–Arg–Phe–Lys–Ser–Pro–Phe–Ala–Leu
Structure: Synthetic peptide fragment derived from human Growth Hormone (176–191)
Metabolic Regulation: Investigated for its ability to mimic the lipolytic effects of hGH without affecting IGF-1 levels.
Adipose Tissue Research: Studied for mechanisms related to the reduction of adipose tissue deposition.
Cartilage Repair: Explored in some preclinical models for potential regenerative effects on cartilage and bone.
Formulation: Lyophilized powder.
Storage: Store lyophilized peptide at -20°C in a dry, dark environment.
Reconstitution: Soluble in water, dilute acetic acid, and buffered saline solutions (e.g., PBS). Reconstituted solutions should be stored at 2–8°C and used within several days. Avoid repeated freeze-thaw cycles.
Purity: ≥99% (HPLC)
Grade: Research Grade
Appearance: White lyophilized powder
Solubility: Soluble in water, dilute acetic acid, and buffered saline solutions.
For Research Use Only. Not for human consumption. While AOD9604 is designed to minimize the insulin-resistance risks associated with hGH, proper laboratory safety protocols must be followed. It is a research chemical intended solely for in vitro and in vivo laboratory study.
Heffernan, M., et al. (2001). “Modulation of adipose tissue deposition by a fragment of growth hormone: a pharmacological profile of AOD9604.” Journal of Endocrinology, 170(3), 471–479.
Ng, F. M., et al. (2000). “Anti-obesity effects of a synthetic peptide fragment of human growth hormone in mice.” Nature Biotechnology, 18, 1217–1220.
Heffernan, M. (2005). “Peptides derived from growth hormone: preclinical and clinical developments of AOD9604.” Clinical and Experimental Pharmacology and Physiology, 32(10), 855–860.
Ng, F. M., & Horvath, A. (2007). “Structure-function relationship of human growth hormone fragment AOD9604.” Peptides, 28(4), 751–760.
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.
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