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5-AMINO-1MQ 10MG
VIAL0001
Test HPLC
Box-01
OVER 80K+
5-AMINO-1MQ 10MG
VIAL0001
Test HPLC
Box-01
OVER 80K+

5-AMINO-1MQ

£37.90

In stock
  • OP Labs, formerly Oxford Peptides.
  • Batch HPLC tested at 99%+ purity.
  • Store frozen long-term or in the fridge when ready to be used.
  • Sold for research purposes only.
  • Contact us for Wholesale Orders.

Description

5-Amino-1MQ is a synthetic methylquinolinium derivative designed as a potent inhibitor of nicotinamide N-methyltransferase (NNMT). In biochemical research systems, it modulates metabolic signaling by interfering with NNMT catalytic activity, thereby influencing levels of methylated nicotinamide derivatives and related metabolites. Peptide Sciences+1

NNMT is a cytosolic enzyme that catalyzes methyl transfer from S-adenosyl methionine (SAM) to nicotinamide and related substrates. Due to its metabolic role, NNMT is expressed in the liver, adipose tissue, kidneys, and other tissues. Peptide Sciences

In preclinical biochemical settings, the inhibition of NNMT by compounds such as 5-Amino-1MQ leads to alterations in intracellular NAD⁺ salvage pathways, shifts in the balance of methyl donors, and downstream changes in metabolic signaling. Peptide Sciences

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  • Download COA here:
Download COA (PDF)

Please note if you have a different Batch ID please contact us for the latest COA.

Chemical Specifications:

Synonyms / Designations: 5-Amino-1-methylquinolinium, 5-Amino-1-MQ, NNMT inhibitor analog
CAS Number: 42464-96-0
Molecular Formula: C₁₀H₁₁N₂⁺ (monocationic quaternary ammonium)
Molar Mass: ~159.21 g/mol
Purity: ≥ 98 % (HPLC, typical)
Appearance: Off-white to pale yellow crystalline powder
Pack Size: 3000 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in water, dilute acids; soluble in polar aprotic solvents (e.g., DMSO)

Description & Mechanism

5-Amino-1MQ is a synthetic methylquinolinium derivative designed as a potent inhibitor of nicotinamide N-methyltransferase (NNMT). In biochemical research systems, it modulates metabolic signaling by interfering with NNMT catalytic activity, thereby influencing levels of methylated nicotinamide derivatives and related metabolites. Peptide Sciences+1

NNMT is a cytosolic enzyme that catalyzes methyl transfer from S-adenosyl methionine (SAM) to nicotinamide and related substrates. Due to its metabolic role, NNMT is expressed in the liver, adipose tissue, kidneys, and other tissues. Peptide Sciences

In preclinical biochemical settings, the inhibition of NNMT by compounds such as 5-Amino-1MQ leads to alterations in intracellular NAD⁺ salvage pathways, shifts in the balance of methyl donors, and downstream changes in metabolic signaling. Peptide Sciences

  • As a molecular probe to study NNMT function, regulation, and downstream metabolic pathways

  • To investigate metabolic flux, methylation dynamics, NAD⁺ salvage, and related bioenergetic phenomena

  • In cellular assays, to test the effects of NNMT inhibition on gene expression, metabolite profiling, or metabolic phenotypes

  • In animal/ex vivo experiments for mechanistic elucidation of metabolic regulation (e.g., adipose tissue, liver)

  • Weigh under inert/dry conditions; avoid moisture uptake

  • For stock solutions, dissolve in water or dilute acid (e.g., 0.1 N HCl) or compatible solvent (e.g, DMSO), depending on assay needs

  • Filter sterilize if needed (e.g., 0.22 µm) immediately before use

  • Aliquot and store stock solutions at –20 °C (or lower) to avoid repeated freeze–thaw

  • Monitor for precipitation or pH shifts before use in sensitive assays

Parameter Typical Value / Range
Purity (HPLC) ≥ 98%
Appearance Off-white to pale yellow powder
Molecular Weight ~159.21 g/mol
Charge State Monocationic (quaternary ammonium)
Solubility Water, dilute acids, DMSO
Storage –20 °C, desiccated, dark
Pack Size 3,000 mg (bulk)

  • Because 5-Amino-1MQ is a small molecule inhibitor with ionic character, buffer composition, ionic strength, and pH in assays may influence its behavior (ion pairing, binding).

  • It is advisable to run appropriate controls (vehicle, dose–response) to exclude non-specific effects in in vitro systems.

  • For in vivo or ex vivo studies (if employed in nonclinical contexts), consider potential biodistribution, clearance, and off-target interactions in experimental design.

  • Use of light, high temperature, or prolonged aqueous exposure may degrade or oxidize the compound; prepare fresh or store stocks under protective conditions.

  1. PeptideSciences (Product information): “What is 5-Amino-1MQ and How Does it Work?” Peptide Sciences

  2. Vendor listing (SwissChems) on 5-Amino-1MQ properties, CAS, formula, etc., swisschems.is

  3. Biochemical/mechanistic discussion of NNMT inhibition and metabolic effects. Peptide Sciences

Keywords: 5amino1mq, 5-amino-1mq, 5-amino.

In stock

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.